diABZI-V/C-Mal

diABZI-V/C-Mal is a STING agonist (with a STING EC50 of 314 nM in TH1 dual reporter cells) and a Cathepsin B substrate. diABZI-V/C-Mal activates STING, thereby triggering the IRF3 signaling pathway. diABZI-V/C-Mal is cleaved by Cathepsin B to regenerate diABZI-NH2 .


Cat. No.: EX-A16193	Purity: >98%

	Chemical structure of diABZI-V/C-Mal

For research only, Do not use for Human!

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CAS No.	3035557-55-9
Purity	>98%
Formula	C67H83N19O14
Mol Weight	1378.4948
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Arora K, et al. Macromolecular Diamidobenzimidazole Conjugates Can Activate Stimulator of Interferon Genes. J Am Chem Soc. 2025;147(38):35149-35163.
CoA	CoA of diABZI-V/C-Mal

Smiles:	C(/C=C/CN1C=2C(N=C1NC(=O)C=3N(CC)N=C(C)C3)=CC(C(N)=O)=CC2OC)N4C=5C(N=C4NC(=O)C=6N(CC)N=C(C)C6)=CC(C(N)=O)=CC5OCCCNC(OCC7=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN8C(=O)C=CC8=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C7)=O


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