Derazantinib hydrochloride

Derazantinib (ARQ-087) dihydrochloride is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3). Derazantinib dihydrochloride inhibits FGFR phosphorylation. Derazantinib dihydrochloride inhibits tumor growth in multiple xenograft models.


Cat. No.: EX-A1717A	Purity: >98%

	Chemical structure of Derazantinib hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	480	in_stock
25mg	622	in_stock
50mg	877	in_stock
100mg	1254	in_stock
250mg	1750	in_stock
500mg	2545	inquire

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Synonyms	ARQ 087 2HCl
Synonyms 2	AQ 14741087
CAS No.	1821329-75-2
Purity	>98%
Formula	C29H30ClFN4O
Mol Weight	505.026
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hall TG, et al. Preclinical Activity of ARQ-087, a Novel Inhibitor Targeting FGFR Dysregulation. PLoS One. 2016 Sep 14;11(9):e0162594. [2]. Balek L, et al. ARQ-087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3. Bone. 2017 Dec;105:57-66.
CoA	CoA of Derazantinib hydrochloride

Smiles:	FC1=C([C@H]2C=3C(C=4C(C2)=CN=C(NC5=CC(CCNCCOC)=CC=C5)N4)=CC=CC3)C=CC=C1.Cl


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