DEL-22379

DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM.


Cat. No.: EX-A1739	Purity: >98%

	Chemical structure of DEL-22379

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	501	in_stock
500mg	761	in_stock
1g	1177	in_stock

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CAS No.	181223-80-3
Purity	>98%
Formula	C26H28N4O3
Mol Weight	444.5255
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Herrero A, et al. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell. 2015 Aug 10;28(2):170-82.
CoA	CoA of DEL-22379

Smiles:	COC1=CC2=C(NC=C2\C=C2/C(=O)NC3=C2C=C(NC(=O)CCN2CCCCC2)C=C3)C=C1


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