DEG-35

DEG-35 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models.


Cat. No.: EX-A15492	Purity: >98%

	Chemical structure of DEG-35

For research only, Do not use for Human!

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CAS No.	2734910-37-1
Purity	>98%
Formula	C25H21N3O5
Mol Weight	443.4513
Color	White to off-white
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Park, Sun-Mi et al. “Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.” Cancer cell vol. 41,4 (2023): 726-739.e11. doi:10.1016/j.ccell.2023.02.010
CoA	CoA of DEG-35

Smiles:	COC1=CC2=C(C=C(C=C2)C(NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3)=O)C=C1


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