Defensin HD 5

HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer .


Cat. No.: EX-A10560	Purity: >98%

	Chemical structure of Defensin HD 5

For research only, Do not use for Human!

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Synonyms	HD 5
Synonyms 2	Human α-defensin 5
CAS No.	798569-33-2
Purity	>98%
Formula	C144H238N50O45S6
Mol Weight	3582.129
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mahendran ASK, et al. The Potential of Antiviral Peptides as COVID-19 Therapeutics. Front Pharmacol. 2020 Sep 15;11:575444. [2]. Gulati NM, et al. α-Defensin HD5 Stabilizes Human Papillomavirus 16 Capsid/Core Interactions. Pathog Immun. 2019 Sep 12;4(2):196-234. [3]. Vragniau C, et al. Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy. J Virol. 2017;91(6):e02030-16. Published 2017 Feb 28.
CoA	CoA of Defensin HD 5

Smiles:	C([C@H]1C(=O)N[C@@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@]3(CSSC[C@@](C(=O)N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CSSC[C@H](NC([C@@H](NC([C@H](C)N)=O)[C@@H](C)O)=O)C(=O)N1)(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](


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