DDO-02267

DDO-02267 is a selective and lysine-targeting covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. DDO-02267 increases N6-methyladenosine (m6A) levels and targets the ALKBH5-AXL signaling axis. DDO-02267 can serve as a probe for investigating the biological function of mRNA demethylase.


Cat. No.: EX-A12893	Purity: >98%

	Chemical structure of DDO-02267

For research only, Do not use for Human!

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CAS No.	2919768-58-2
Purity	>98%
Formula	C18H12N2O7S
Mol Weight	400.362
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fei WL, et al. Discovery of the salicylaldehyde-based compound DDO-02267 as a lysine-targeting covalent inhibitor of ALKBH5. Eur J Med Chem. 2024 Dec 23;284:117183.
CoA	CoA of DDO-02267

Smiles:	O=CC1=C(O)C2=C(C=CC=C2)C(S(=O)(NC(C3=NC=CC(C(O)=O)=C3)=O)=O)=C1


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