DCP-LA

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .


Cat. No.: EX-A10127	Purity: >98%

	Chemical structure of DCP-LA

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	550	In-stock
100mg	825	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock
1g	2500	In-stock
5g	get quote	Inquire

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Synonyms	FR 236924
Synonyms 2	DCPLA
CAS No.	28399-31-7
Purity	>98%
Formula	C20H36O2
Mol Weight	308.4986
Color	, colorless to light yellow
State	liquid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Pure form 4℃ 2 years, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37(1):193-200. [2]. Kanno T, et al. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol. 2009 Oct;221(1):183-8. [3]. Yaguchi T, et al. Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res. 2010 May;35(5):712-7.
CoA	CoA of DCP-LA

Smiles:	CCCCCC1CC1CC2CC2CCCCCCCC(=O)O


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