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Product Information:

DCN1-IN-2

DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3.

Cat. No.: EX-A13384    Purity: >98%
Chemical
Chemical structure of DCN1-IN-2


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg528contact us for price and avail
25mg732contact us for price and avail
100mg1450contact us for price and avail
500mgget quotecontact us for price and avail
1gget quotecontact us for price and avail


CAS No.2543578-57-8
Purity>98%
FormulaC18H14ClF3N4OS
Mol Weight426.843
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. He ZX, et al. Discovery of 1,2,4-Triazole-3-thione Derivatives as Potent and Selective DCN1 Inhibitors for Pathological Cardiac Fibrosis and Remodeling. J Med Chem. 2024 Aug 19.

CoACoA of DCN1-IN-2
Smiles:O=C(CCN1C(NN=C1C2=CC=C(Cl)C=C2)=S)NC3=CC=CC(C(F)(F)F)=C3

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