DC0-NH2

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.


Cat. No.: EX-A12591	Purity: >98%

	Chemical structure of DC0-NH2

For research only, Do not use for Human!

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CAS No.	615538-51-7
Purity	>98%
Formula	C31H24ClN5O3
Mol Weight	550.007
Color	Light brown to brown
State	solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, stored under nitrogen; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.
CoA	CoA of DC0-NH2

Smiles:	C(Cl)[C@H]1C2=C(N(C(=O)C=3NC=4C(C3)=CC(NC(=O)C=5NC=6C(C5)=CC(N)=CC6)=CC4)C1)C=C(O)C=7C2=CC=CC7


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