dBRD9 dihydrochloride

dBRD9 dihydrochloride is a BRD9 PROTAC degrader. dBRD9 dihydrochloride reduces the binding of the ISGF3 complex to ISG promoters, decreases the level of ISG induction downstream of IFNAR signaling, and reduces the chromatin binding of BRD4 at BRD9 co-binding sites. dBRD9 dihydrochloride can be used in research related to acute myeloid leukemia .


Cat. No.: EX-A7278	Purity: >98%

	Chemical structure of dBRD9 dihydrochloride

For research only, Do not use for Human!

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Synonyms	dBRD9
CAS No.	2341840-98-8
Purity	>98%
Formula	C40H46ClN7O10
Mol Weight	820.287
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Storage	4°C, sealed storage, away from moisture and light In solvent : -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angewandte Chemie (International ed. in English). 2017 May 15;56(21):5738-5743. [2].Ahmed NS, et al. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proceedings of the National Academy of Sciences of the United States of America. 2022 Jan 04;119(1):e2110812119.
CoA	CoA of dBRD9 dihydrochloride


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