DBPR116

DBPR116 is a prodrug of BPRMU191 (HY-159923) with blood-brain barrier penetration capability. DBPR116 significantly improves the delivery of centrally targeted drugs. In combination with the antagonist Naltrexone (HY-76711), DBPR116 demonstrated superior safety and analgesic efficacy compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a prodrug strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing potential as a safer opioid analgesic .


Cat. No.: EX-A16207	Purity: >98%

	Chemical structure of DBPR116

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
0.5g	get quote	inquire
1g	get quote	inquire
5g	get quote	inquire
10g	get quote	inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2131200-75-2
Purity	>98%
Formula	C19H18FNO3S
Mol Weight	359.415
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Lin SY, et al. DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration. J Med Chem. 2024 Nov 14;67(21):19777-19790.
CoA	CoA of DBPR116

Smiles:	O=C(OCC)C1=CC=C(C(=C1)C)N2C(=O)CSC2C3=CC=C(F)C=C3


		Search