DBCO-PEG4-Val-Cit-PAB-MMAE

DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE. DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.


Cat. No.: EX-A5871	Purity: >95%

	Chemical structure of DBCO-PEG4-Val-Cit-PAB-MMAE

For research only, Do not use for Human!

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CAS No.	2129164-91-4
Purity	>95%
Formula	C88H128N12O19
Mol Weight	1658.0269
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO ? 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.
CoA	CoA of DBCO-PEG4-Val-Cit-PAB-MMAE


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