DB008

DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Cat. No.: EX-A8687	Purity: >98%

	Chemical structure of DB008

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1150	Inquire
100mg	1750	Inquire
250mg	get quote	Inquire
500mg	get quote	Inquire
1g	4800	Inquire

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CAS No.	2991637-98-8
Purity	>98%
Formula	C25H21FN4O3
Mol Weight	444.4576
Color	white to off-white
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder protect from light; 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bejan DS, et, al. Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor. Chem Sci. 2022 Nov 16;13(46):13898-13906.
CoA	CoA of DB008

Smiles:	O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C=C)=O)CC3)=O)=C2)C4=C1C=CC(C#C)=C4


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