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Product Information:

Danoprevir

Danoprevir (RG7227) is a potent and selective inhibitor of Hepatitis C Virus (HCV) NS3/4A protease.

Cat. No.: EX-A2045    Purity: >98%
Chemical
Chemical structure of Danoprevir


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg750In-stock
250mg1150In-stock
500mg1850In-stock
1g2880Inquire
5g7800Inquire


SynonymsITMN-191
Synonyms 2RO5190591
CAS No.850876-88-9
Purity>98%
FormulaC35H46FN5O9S
Mol Weight731.831
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Forestier N, Larrey D, Guyader D, Marcellin P, Rouzier R, Patat A, Smith P, Bradford W, Porter S, Blatt L, Seiwert SD, Zeuzem S. Treatment of Chronic Hepatitis C Patients with the NS3/4A Protease Inhibitor Danoprevir (ITMN-191/RG7227) Leads to Robust Reductions in Viral RNA: A Phase 1b Multiple Ascending Dose Study. J Hepatol. 2010 Dec 8. [Epub ahead of print] PubMed PMID: 21145848.

[5]. Deutsch M, Papatheodoridis GV. Danoprevir, a small-molecule NS3/4A protease inhibitor for the potential oral treatment of HCV infection. Curr Opin Investig Drugs. 2010 Aug;11(8):951-63. PubMed PMID: 20721837.
CoACoA of Danoprevir
Smiles:[H][C@]12C[C@@]1(NC(=O)[C@@]1([H])C[C@@H](CN1C(=O)[C@@H](CCCCC\C=C\2)NC(=O)OC(C)(C)C)OC(=O)N1CC2=C(C1)C(F)=CC=C2)C(=O)NS(=O)(=O)C1CC1

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