Dac590

Dac590 is an orally active and selective obesity-associated protein (FTO) inhibitor with an IC50 of 6.06 nM. Dac590 shows highly selective over ALKBH5 and ALKBH3. Dac590 suppresses oncogenic FTO signaling, induces myeloid differentiation, G1-phase cell cycle arrest, and apoptosis in acute myeloid leukemia (AML) cells. Dac590 inhibits xenograft tumor growth and prolongs survival in acute myeloid leukemia mouse models with no observed toxicity. Dac590 can be used for the research of AML.


Cat. No.: EX-A13645	Purity: >98%

	Chemical structure of Dac590

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	642	in-stock
250mg	995	in-stock
500mg	1550	in-stock
1g	2150	in-stock

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CAS No.	3084407-00-8
Purity	>98%
Formula	C19H16ClFN2O4
Mol Weight	390.793
Color	Yellow to brown
State	Solid
Solubility	DMSO : 12.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang T, et al. Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy. J Med Chem. 2025;68(13):13714-13727.
CoA	CoA of Dac590

Smiles:	OC(C1=CC(OC)=CC=C1NC2=C(C=C(C=C2Cl)C3=C(ON=C3C)C)F)=O


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