D223

DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research.


Cat. No.: EX-A13705	Purity: >98%

	Chemical structure of D223

For research only, Do not use for Human!

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Synonyms	DS02312223
CAS No.	2253733-45-6
Purity	>98%
Formula	C29H32FN5O5S
Mol Weight	581.658
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Terayama K,et al. Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin. Science. 2025 Jul 24;389(6758):402-408.
CoA	CoA of D223

Smiles:	O=C(OC(C)(C)C)NCCOCCOC1=CC=CC=C1C=2N=NC(NC3=CC=C(C=C3F)CC(=O)N)=C4C=CSC24


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