CYP51/PD-L1-IN-2

CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.


Cat. No.: EX-A12940	Purity: >98%

	Chemical structure of CYP51/PD-L1-IN-2

For research only, Do not use for Human!

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CAS No.	3032386-58-3
Purity	>98%
Formula	C25H23N7O3
Mol Weight	469.4952
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sun B, et al. Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties. J Med Chem. 2023 Sep 13.. .
CoA	CoA of CYP51/PD-L1-IN-2

Smiles:	O=C(NC1CCN(C(=O)C2=CC=C(C=C2)C(=O)C)CC1)C=3N=C4C=CC=CC4=C(N3)N5N=CN=C5


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