CYP51/PD-L1-IN-1

CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-1 is a dual inhibitor of CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-1 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.


Cat. No.: EX-A12930	Purity: >98%

	Chemical structure of CYP51/PD-L1-IN-1

For research only, Do not use for Human!

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CAS No.	3032386-49-2
Purity	>98%
Formula	C20H15N5O2
Mol Weight	357.3654
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sun B, et al. Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties. J Med Chem. 2023 Sep 13.. .
CoA	CoA of CYP51/PD-L1-IN-1

Smiles:	O=C(NC1=CC=C(C=C1)C(=O)C)C=2N=C3C=CC=CC3=C(N2)N4C=NC=C4


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