CYP121A1-IN-1

CYP121A1-IN-1 is a potent CYP121A1 inhibitor with favorable activity against Mycobacterium tuberculosis (H37Rv MIC90～6.25 μM, ～2.2 μg/mL). CYP121A1-IN-1 can markedly reduce the production of mycocyclosin via inhibiting the CYP121A1 mediated turnover of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin.


Cat. No.: EX-A12920	Purity: >98%

	Chemical structure of CYP121A1-IN-1

For research only, Do not use for Human!

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CAS No.	3033296-80-6
Purity	>98%
Formula	C22H20N4O
Mol Weight	356.4204
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Frederickson M, et al. A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). Eur J Med Chem. 2022;230:114105.
CoA	CoA of CYP121A1-IN-1

Smiles:	N=1C=CC(=NC1N2C=3C=CC=CC3OCC2)CCC4=CNC=5C=CC=CC54


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