CXM102

CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice.


Cat. No.: EX-A12836	Purity: >98%

	Chemical structure of CXM102

For research only, Do not use for Human!

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Purity	>98%
Formula	C28H27NO3
Mol Weight	425.5189
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Luo Z, et al. Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice. Bone Res. 2024 Aug 21;12(1):45.
CoA	CoA of CXM102

Smiles:	O=C(NC1=CC=CC(C)=C1C)[C@H]2[C@@H](C(O)=O)C(C3=CC=CC=C3)C=CC2C4=CC=CC=C4


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