CXD101

CXD101 is a potent class 1 selective HDAC inhibitor with IC50s of 63 nM, 570 nM, 550 nM for HDAC1, HDAC2, and HDAC3, respectively. CXD101 has no activity against class 2 HDAC. CXD101 demonstrates potent antiproliferative activity against various cancer cells in vitro.


Cat. No.: EX-A1143	Purity: >98%

	Chemical structure of CXD101

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	720	In-stock
5g	2520	In-stock
10g	3985	In-stock

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Synonyms	HDAC-IN-4
CAS No.	934828-12-3
Purity	>98%
Formula	C24H29N5O
Mol Weight	403.52
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma - the holy grail for HDAC inhibitors? Oncotarget. 2018 Dec 18;9(99):37280-37281. [2]. Eyre TA, et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer. 2019 Jan 1;125(1):99-108.
CoA	CoA of CXD101

Smiles:	CN1C=C(CN2CCC(CC2)C2=CC=C(C=C2)C(=O)NC2=CC=CC=C2N)C(C)=N1


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