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Product Information:

CWHM-12

CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).

Cat. No.: EX-A850    Purity: >98%
Chemical
Chemical structure of CWHM-12


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg450In-stock
250mg850In-stock
250mg1250In-stock
1g1800In-stock
2g3300In-stock
5gget quoteIn-stock


CAS No.1564286-55-0
Purity>98%
FormulaC26H32BrN5O6
Mol Weight590.466
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Henderson NC, et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24.

[2]. Basta J, Robbins L, Stout L, Prinsen MJ, Griggs DW, Rauchman M. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiol Rep. 2020;8(7):e14329.

CoACoA of CWHM-12
Smiles:CC(C)(C)C1=CC(Br)=CC(=C1)[C@H](CC(O)=O)NC(=O)CNC(=O)C1=CC(O)=CC(NC2=NCC(O)CN2)=C1

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