CU-CPD107

Small-mol. modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clin. uses are limited because they can invoke an uncontrolled, global inflammatory response. The efforts described herein culminate in the fortuitous discovery of a tetrasubstituted imidazole CU-CPD107 which inhibits R848-induced TLR8 signaling. In stark contrast, CU-CPD107 shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling. CU-CPD107's unique, dichotomous behavior sheds light on a way to approach TLR agonists. CU-CPD107 offers the opportunity to avoid the undesired, global inflammation side effects that have rendered imidazoquinolines clin. irrelevant, providing an insight for the development of antiviral drugs.


Cat. No.: EX-A5587	Purity: >98%

	Chemical structure of CU-CPD107

For research only, Do not use for Human!

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CAS No.	2573912-32-8
Purity	>98%
Formula	C16H21IN2O2
Mol Weight	400.2546
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 125 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang, Yi; Csakai, Adam; Jiang, Shuangshuang; Smith, Christina; Tanji, Hiromi; Huang, Jian; Jones, Torey; Sakaniwa, Kentaro; Broadwell, Lindsey; Shi, Chengrui; et al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nature Communications (2021), 12(1), 4351.
CoA	CoA of CU-CPD107


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