CT-179

CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma .


Cat. No.: EX-A16478	Purity: >98%

	Chemical structure of CT-179

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	520	In-stock
100mg	820	In-stock
250mg	1630	In-stock
500mg	2600	In-stock
1g	4120	In-stock
2g	6600	In-stock

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CAS No.	1996636-69-1
Purity	>98%
Formula	C17H22Cl2N6O
Mol Weight	397.302
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Li Y, et al. Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nat Commun. 2025;16(1):1091. Published 2025 Feb 4.
CoA	CoA of CT-179

Smiles:	CC1=CC(=NC(=N1)NC(=O)NC2=CC(=C(C=C2)Cl)Cl)NCCCN(C)C


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