CSN5i-3

CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM .


Cat. No.: EX-A8597	Purity: >98%

	Chemical structure of CSN5i-3

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1480	In-stock
100mg	2480	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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CAS No.	2375740-98-8
Purity	>98%
Formula	C28H29F2N5O2
Mol Weight	505.559
Color	white to light yellow
State	solid powder
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7:13166.
CoA	CoA of CSN5i-3

Smiles:	O=C(C1=CC(C(F)F)=NN1C(C)C)NC2=CC(C3=CC=CC=C3)=C([C@@H]4N5C(CCC[C@@H]4O)=CN=C5)C=C2


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