CS4

CS4 is a selective HDAC inhibitor with the IC50 values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes α-tubulin and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro.


Cat. No.: EX-A13692	Purity: >98%

	Chemical structure of CS4

For research only, Do not use for Human!

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CAS No.	3062988-80-8
Purity	>98%
Formula	C16H20N2O3
Mol Weight	288.3416
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang L, et al. Discovery of cloxiquine derivatives as potent HDAC inhibitors for the treatment of melanoma via activating PPARγ. Eur J Med Chem. 2025 Jan 5;281:117029.
CoA	CoA of CS4

Smiles:	O=C(NO)CCCCCCOC=1C=CC=C2C=CC=NC12


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