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Product Information:

CPUY192018

CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM.

Cat. No.: EX-A10806    Purity: >98%
Chemical
Chemical structure of CPUY192018


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg535in_stock
250mg1068in_stock
500mg2127in_stock
1g3398in_stock
2g5394in_stock
3g6605in_stock


CAS No.1567836-15-0
Purity>98%
FormulaC28H26N2O10S2
Mol Weight614.643
Coloroff-white to light yellow
Statesolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Lu MC, et al. CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation. Redox Biol. 2019 Sep;26:101266.

[2]. Lee S, et al. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022; 237:114380.

CoACoA of CPUY192018
Smiles:O=C(O)CN(C1=C2C=CC=CC2=C(N(S(=O)(C3=CC=C(OC)C=C3)=O)CC(O)=O)C=C1)S(=O)(C4=CC=C(OC)C=C4)=O

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