CPT166

Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research.


Cat. No.: EX-A13734	Purity: >98%

	Chemical structure of CPT166

For research only, Do not use for Human!

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CAS No.	2378619-11-3
Purity	>98%
Formula	C24H22FN3O6
Mol Weight	467.4464
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 3.85 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li W, et al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392.
CoA	CoA of CPT166

Smiles:	O=C1N2C(C=3C(C2)=C(CNC(CO)=O)C=4C(N3)=CC(F)=C(C)C4)=CC5=C1COC(=O)[C@@]5(CC)O


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