CPI-637

CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.


Cat. No.: EX-A2386	Purity: >98%

	Chemical structure of CPI-637

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	600	In-stock
200mg	900	In-stock
500mg	1250	In-stock
1g	1750	In-stock
5g	6125	In-stock

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CAS No.	1884712-47-3
Purity	>98%
Formula	C22H22N6O
Mol Weight	386.4497
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Taylor AM, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.
CoA	CoA of CPI-637

Smiles:	C[C@@H]1CC(=O)NC2=CC=CC(C3=CC4=C(C=C3)N(C)N=C4C3=CN(C)N=C3)=C2N1


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