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Product Information:

CPI-203

CPI-203 is a novel potent, selective and cell permeable inhibitor of BET bromodomain, with an IC50 value of appr 37 nM (BRD4 α-screen assay).

Cat. No.: EX-A456    Purity: >98%
Chemical
Chemical structure of CPI-203


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg596in_stock
500mg924in_stock
1g1630in_stock
2g2566in_stock
5g4969in_stock
10g8158in_stock


CAS No.1446144-04-2
Purity>98%
FormulaC19H18ClN5OS
Mol Weight399.897
ColorLight yellow to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Devaiah BN, et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6927-32.

[2]. Moros A, et al. Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia. 2014 Oct;28(10):2049-59

CoACoA of CPI-203
Smiles:CC1=NN=C2[C@H](CC(N)=O)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1

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