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Product Information:

CP5V

CP5V is a PROTAC connected by ligands for von Hippel-Lindau and CDK, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation.

Cat. No.: EX-A7594    Purity: >98%
Chemical
Chemical structure of CP5V


For research only, Do not use for Human!

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CAS No.2509359-75-3
Purity>98%
FormulaC46H66Cl3N9O12S
Mol Weight1075.493
ColorOff-white to light yellow
Statesolid powder
SolubilityDMSO : 150 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃, stored under nitrogen In solvent : -80℃, 6 months; -20℃, 1 month (stored under nitrogen)
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

CoACoA of CP5V

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