CP 94253 hydrochloride

CP94253 hydrochloride is an orally active, brain-penetrant and selective 5-HT1B receptor agonist with an Ki of 2 nM. CP94253 hydrochloride induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 hydrochloride can be used for the research of depression and heightened aggressive behavior.


Cat. No.: EX-A11530	Purity: >98%

	Chemical structure of CP 94253 hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
500mg	852	In-stock
1g	1192	In-stock

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CAS No.	845861-39-4
Purity	>98%
Formula	C15H20ClN3O
Mol Weight	293.792
Color	Light yellow to yellow
State	solid
Solubility	DMSO : 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Schreiber R, et al. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(3):441-449. [2]. Tatarczyńska E, et al. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. Eur J Pharmacol. 2005;516(1):46-50. [3]. Monti JM, et al. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. [4]. Koe KB, et al. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev. Res. 1992;26:241-250. [5]. Fish EW, et al. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology (Berl). 1999;146(4):391-399. [6]. Lee MD, et al. CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berl). 1997;131(3):264-270.
CoA	CoA of CP 94253 hydrochloride

Smiles:	CCCOC1=NC2=C(C=C1)NC=C2C3=CCNCC3.Cl


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