Product Information:

CP-481715

CP-481715 is a potent, reversible and selective CCR1 antagonist with a Kd of 9.2 nM for human CCR1. CP-481715 is >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481715 has the potential for rheumatoid arthritis and other inflammatory diseases research .


Cat. No.: EX-A10767	Purity: >98%

	Chemical structure of CP-481715

For research only, Do not use for Human!

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CAS No.	212790-31-3
Purity	>98%
Formula	C26H31FN4O4
Mol Weight	482.5471
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gladue RP, Tylaska LA, Brissette WH, Lira PD, Kath JC, Poss CS, Brown MF, Paradis TJ, Conklyn MJ, Ogborne KT, McGlynn MA, Lillie BM, DiRico AP, Mairs EN, McElroy EB, Martin WH, Stock IA, Shepard RM, Showell HJ, Neote K.CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.J Biol Chem. 2003 Oct 17;278(42):40473-80. Epub 2003 Aug 7. [2]. Borregaard J, Skov L, Wang L, Ting N, Wang C, Beck LA, Sonne J, Clucas A.Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects.Contact Dermatitis. 2008 Oct;59(4):212-9. [3]. Gladue RP, Cole SH, Roach ML, Tylaska LA, Nelson RT, Shepard RM, McNeish JD, Ogborne KT, Neote KS.The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.J Immunol. 2006 Mar 1;176(5):3141-8. [4]. Ronald P Gladue, et al. CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278(42):40473-80.
CoA	CoA of CP-481715

Smiles:	O=C(C1=NC2=CC=CC=C2N=C1)N[C@@H](CC3=CC=CC(F)=C3)[C@@H](O)C[C@H](C(N)=O)CCC(C)(O)C


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