CP-10

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6 .


Cat. No.: EX-A8730	Purity: >98%

	Chemical structure of CP-10

For research only, Do not use for Human!

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Synonyms	CP-10
CAS No.	2366268-80-4
Purity	>98%
Formula	C44H49N13O7
Mol Weight	871.9428
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO: 200 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
CoA	CoA of CP-10

Smiles:	CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O


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