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Product Information:

COX-2/NLRP3-IN-1

COX-2/NLRP3-IN-1 (Compound 6k) is a COX-2/NLRP3 inhibitor with a IC50 of 1.53 μM for COX-2. COX-2/NLRP3-IN-1 exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway .

Cat. No.: EX-A15820    Purity: >98%
Chemical
Chemical structure of COX-2/NLRP3-IN-1


For research only, Do not use for Human!

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CAS No.3057274-61-7
Purity>98%
FormulaC24H19Cl2N5OS
Mol Weight496.412
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ju Z, et al. Structural modification based on the diclofenac scaffold: Achieving reduced colitis side effects through COX-2/NLRP3 selective inhibition. Eur J Med Chem. 2024 Feb 17;268:116257.

CoACoA of COX-2/NLRP3-IN-1
Smiles:ClC1=C(NC2=CC=CC=C2CC3=NN=C4N3N=C(C5=C(OC)C=CC=C5)CS4)C(Cl)=CC=C1

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