Conoidin A

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.


Cat. No.: EX-A5048	Purity: >98%

	Chemical structure of Conoidin A

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	600	In-stock
1g	800	In-stock
5g	2650	In-stock

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CAS No.	18080-67-6
Purity	>98%
Formula	C10H8Br2N2O2
Mol Weight	347.991
Color	White to yellow
State	solid powder
Solubility	Soluble in DMSO 14.29 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jeralyn D Haraldsen, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048. [2]. Gu Liu, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5. [3]. Bo Wei, et al. Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. Br J Pharmacol
CoA	CoA of Conoidin A

Smiles:	BrCC1=C(CBr)[N+]([O-])=C2C=CC=CC2=[N+]1[O-]


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