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Product Information:

Complement C1s-IN-1

Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM.

Cat. No.: EX-A16135    Purity: >98%
Chemical
Chemical structure of Complement C1s-IN-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1mg1020In-stock
5mg2050In-stock


CAS No.3033831-40-9
Purity>98%
FormulaC22H20F2N6O
Mol Weight422.4306
ColorOff-white to light yellow
StateSolid
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ikeda Z, et al. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 Apr 25.

CoACoA of Complement C1s-IN-1
Smiles:NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1

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