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Product Information:

Clezutoclax

Clezutoclax is a potent payload and also a Bcl-XL inhibitor. Clezutoclax can be used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.: EX-A11437    Purity: >98%
Chemical
Chemical structure of Clezutoclax


For research only, Do not use for Human!

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CAS No.1949843-71-3
Purity>98%
FormulaC83H102N12O24S2
Mol Weight1715.894
 
 
Reference:  

[1]. Boni V, et al. The Resurgence of Antibody Drug Conjugates in Cancer Therapeutics: Novel Targets and Payloads. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-17.

CoACoA of Clezutoclax
Smiles:O=C(OCC(C=CC(NC([C@H](C)NC([C@H](C(C)C)NC(CN(C1=O)[C@@H](C[C@@H]1N(C2=O)C(C=C2)=O)COCC[S](=O)(O)=O)=O)=O)=O)=C3)=C3CC[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)C(O)=O)N(CC[C@H](O)CO)CCO[C@](C5)(C6)C[C@@](C[C@@]6(C7)C)(C[C@]57C)CN8C(C)=C(C(C=CC(N(CCC9=CC=C%10

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