Product Information:

Clazosentan

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.


Cat. No.: EX-A10533	Purity: >99%

	Chemical structure of Clazosentan

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	300	In-stock
250mg	450	In-stock
500mg	680	In-stock
1g	1072	In-stock
5g	3200	In-stock
10g	4876	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	Ro-61-1790
Synonyms 2	ACT-108475
CAS No.	180384-56-9
Purity	>99%
Formula	C25H23N9O6S
Mol Weight	577.572
Color	Off-white to light yellow
State	solid powder
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder: -20℃, sealed storage, 3 years; In solvent: -20℃, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Juif PE, et al. Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm. Front Pharmacol. 2021 Feb 4;11:628956. [2]. Juif PE, et al. Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan. Clin Transl Sci. 2019 Sep;12(5):440-444. [3]. Povlsen GK, et al. MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats. J Cereb Blood Flow Metab. 2015 Feb;35(2):329-37. [4]. Vatter H, et al. Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist clinically effective for the treatment of cerebral vasospasm. Part I: inhibitory effect on endothelin(A) receptor-mediated contraction. J Neurosurg. 2005 Jun;102(6):1101-7. [5]. Verri WA Jr, Guerrero AT, Fukada SY, Valerio DA, Cunha TM, Xu D, Ferreira SH, Liew FY, Cunha FQ. IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2723-8.
CoA	CoA of Clazosentan

Smiles:	O=S(=O)(NC1=NC(=NC(OCCO)=C1OC=2C=CC=CC2OC)C3=CC=NC(=C3)C4=NN=NN4)C5=NC=C(C=C5)C


		Search