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Product Information:

CK1δ-IN-9

CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance.

Cat. No.: EX-A16319    Purity: >98%
Chemical
Chemical structure of CK1δ-IN-9


For research only, Do not use for Human!

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CAS No.3057263-82-5
Purity>98%
FormulaC16H12FN5
Mol Weight293.2984
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. McCarver S, et al., Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions. ACS Med Chem Lett. 2024 Mar 7;15(4):486-492.

CoACoA of CK1δ-IN-9
Smiles:FC1=CC=C(C2=NN(C)C=C2C3=C4C=NNC4=NC=C3)C=C1

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