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Product Information:

Cilobradine hydrochloride

Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects.

Cat. No.: EX-A11244    Purity: >98%
Chemical
Chemical structure of Cilobradine hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg795In-stock
500mg1120In-stock
1g1580In-stock
2g2680In-stock
5g5520In-stock


SynonymsDK-AH 269
CAS No.186097-54-1
Purity>98%
FormulaC28H39ClN2O5
Mol Weight519.073
ColorWhite to off-white
Statesolid
SolubilityDMSO : ? 125 mg/mL H2O : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4℃, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.

[2]. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

[3]. Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69(4):1328-37.

[4]. Umeya N, et al. Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats. Exp Eye Res. 2024 Apr;241:109847.

[5]. Cai M, et al. HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model. Neurobiol Stress. 2023 Aug 19;26:100565.

CoACoA of Cilobradine hydrochloride
Smiles:O=C1N(C[C@@H]2CN(CCC3=CC=C(OC)C(OC)=C3)CCC2)CCC4=CC(OC)=C(OC)C=C4C1.[H]Cl

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