Chroman 1

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM.


Cat. No.: EX-A10946	Purity: >98%

	Chemical structure of Chroman 1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	768	In-stock
250mg	1308	In-stock
500mg	1968	In-stock
1g	2858	In-stock

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CAS No.	1273579-40-0
Purity	>98%
Formula	C24H28N4O4
Mol Weight	436.5035
Color	White to pink
State	Solid
Solubility	DMSO : ? 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yu Chen, et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells. bioRxiv 815761. [2]. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.
CoA	CoA of Chroman 1

Smiles:	O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C


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