ChREBPα/14-3-3 regulator-1

ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with 14-3-3 proteins (EC50: 3.8 μM). ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes.


Cat. No.: EX-A17083	Purity: >98%

	Chemical structure of ChREBPα/14-3-3 regulator-1

For research only, Do not use for Human!

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CAS No.	3067202-14-3
Purity	>98%
Formula	C16H15F3NO5P
Mol Weight	389.263
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Katz LS, et al. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv [Preprint]. 2024 Nov 17:2024.02.16.580675.
CoA	CoA of ChREBPα/14-3-3 regulator-1

Smiles:	FC1=CC=CC(C(F)(F)CNC(COC2=C(P(O)(O)=O)C=CC=C2)=O)=C1


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