Chk1-IN-6

Chk1-IN-6 is a selective and orally active Chk1 inhibitor with an IC50 of 16.1 nM. Chk1-IN-6 shows antiproliferative activity of MV-4-11 cells. Chk1-IN-6 exerts effective response in the MV-4-11 xenograft mouse model. Chk1-IN-6 exhibits synergistic anticancer effect with Gemcitabine. Chk1-IN-6 can be used in the research of cancers such as acute myeloid leukemia and colorectal adenocarcinoma.


Cat. No.: EX-A16983	Purity: >98%

	Chemical structure of Chk1-IN-6

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	498	in_stock
25mg	1016	in_stock
50mg	1566	in_stock
100mg	2386	in_stock

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CAS No.	2428423-77-0
Purity	>98%
Formula	C16H18F3N7
Mol Weight	365.3562
Color	White to off-white
State	Solid
Solubility	DMSO : 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090.
CoA	CoA of Chk1-IN-6

Smiles:	N#CC(C=C1)=NC=C1NC2=NC=C(C(F)(F)F)C(NCCC(C)(C)N)=N2


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