CHK1-IN-12

CHK1-IN-12 is an oral, potent, and selective small molecule inhibitor of CHK1 with an IC50 of 0.3 nM. It demonstrates significant anti-tumor activity as a single agent and in combination with targeted therapies in multiple ecDNA+ oncogene amplified tumor models.


Cat. No.: EX-A11468	Purity: >98%

	Chemical structure of CHK1-IN-12

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	CHK1-IN-12
CAS No.	2871056-82-3
Purity	>98%
Formula	C19H19N7O2
Mol Weight	377.3999
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jiang K, et al. Medicine in Drug Discovery, 2024: 100185. [2]. Maron SB, et al. 2025.
CoA	CoA of CHK1-IN-12

Smiles:	O(C1=C(C(OC)=CC=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2)[C@@H]4C[C@@H](N)C4


		Search