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Product Information:

CHIR-124

CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.

Cat. No.: EX-A14120    Purity: >98%
Chemical
Chemical structure of CHIR-124


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg525In-stock
500mg872In-stock
1g1320In-stock
5g4680Inquire


CAS No.405168-58-3
Purity>98%
FormulaC23H22ClN5O
Mol Weight419.907
ColorLight yellow to brown
StateSolid
SolubilityDMSO : 7.14 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13(2 Pt 1), 591-602.

[2]. Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16(2), 376-383.

CoACoA of CHIR-124
Smiles:ClC1=CC2=C(NC(C(C3=NC4=C(C=CC=C4)N3)=C2N[C@@H]5CN6CCC5CC6)=O)C=C1

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