Chemerin15

Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury.


Cat. No.: EX-A13627	Purity: >98%

	Chemical structure of Chemerin15

For research only, Do not use for Human!

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CAS No.	1020407-90-2
Purity	>98%
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder 80°C, 2 years , -20°C, 1 year, Sealed storage, away from moisture; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cash JL, et al. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner. J Immunol. 2010;184(9):5315-5324. [2]. Yang Y, et al. Chemerin 15 enhances microglial phagocytosis to attenuate cerebral ischemia-reperfusion injury through the ChemR23/p38 MAPK pathway. iScience. 2025;28(9):113396. Published 2025 Aug 19. [3]. Cash JL, et al. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO Rep. 2013;14(11):999-1007.
CoA	CoA of Chemerin15

Smiles:	Ala-Gly-Glu-Asp-Pro-His-Gly-Tyr-Phe-Leu-Pro-Gly-Gln-Phe-Ala


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