Ch282-5

Ch282-5 is an orally active inhibitor targeting the Bcl-2 protein, inducing mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. Ch282-5 exhibits antiproliferative activity against colorectal cancer cells both in vitro and in vivo, and it also inhibits metastasis. Additionally, Ch282-5 enhances Oxaliplatin-induced autophagy (Autophagy) by downregulating the Mcl-1 protein and increasing platelet count, alleviating adverse effects of Navitoclax.


Cat. No.: EX-A13242	Purity: >98%

	Chemical structure of Ch282-5

For research only, Do not use for Human!

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CAS No.	65891-87-4
Purity	>98%
Formula	C34H37N2NaO14S2
Mol Weight	784.782
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang X, et al. A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria. Clin Cancer Res. 2016 Mar 15;22(6):1445-58.
CoA	CoA of Ch282-5

Smiles:	[Na].O=C1C=2C(C=NCCS(=O)(=O)O)=C(O)C(O)=C(C2C(=O)C(=C1C=3C(=O)C=4C(C=NCCS(=O)(=O)O)=C(O)C(O)=C(C4C(=O)C3C)C(C)C)C)C(C)C


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