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Product Information:

CGRP antagonist 7

CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with an IC50 of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine.

Cat. No.: EX-A13624    Purity: >98%
Chemical
Chemical structure of CGRP antagonist 7


For research only, Do not use for Human!

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CAS No.2173508-07-9
Purity>98%
FormulaC30H32FN5O3
Mol Weight529.6052
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Morita N, et al. Fragment-Based Discovery of an Oral Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine. J Med Chem. 2025 Jul 24;68(14):14919-14944.

CoACoA of CGRP antagonist 7
Smiles:CC1=NNC(C(CC2=CC=C(C=C2C)C(NCC(N3[C@@H](CC[C@@H]3C(C)(C#N)C)C4=CC(F)=CC=C4)=O)=O)=C1)=O

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