cGAMP

cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.


Cat. No.: EX-A2911	Purity: >98%

	Chemical structure of cGAMP

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1850	In-stock
250mg	3250	In-stock
500mg	4850	In-stock
1g	7865	In-stock

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Synonyms	Cyclic GMP-AMP
Synonyms 2	3',3'-cGAMP
CAS No.	849214-04-6
Purity	>98%
Formula	C20H24N10O13P2
Mol Weight	674.4113
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. [2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. [3]. Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18. [4]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
CoA	CoA of cGAMP

Smiles:	NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@@H]4[C@@H](COP(O)(=O)O[C@H]3[C@H]2O)O[C@H]([C@@H]4O)N2C=NC3=C2N=CN=C3N)C(=O)N1


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